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STINGING INSECT ALLERGY What Is an Insect Allergy? An insect allergy develops because your immune system overreacts to an insect sting. The first time you are stung, your body produces a protein known as immunoglobulin E (IgE) antibody, specific to the venom that was injected when the insect stung you. If you are stung again by the same kind of insect, the venom will react with the IgE and activate the release of histamine and other chemicals, launching an allergic reaction. A serious insect allergy can result in a life-threatening condition called anaphylaxis, which can affect your whole body. If you have had a relatively severe local reaction to an insect sting (for example, a larger area of swelling around the sting that persists for days or weeks), you may be sensitized to the insect venom and at risk of an anaphylactic reaction if you are stung again. Anaphylaxis is a medical emergency that requires immediate medical treatment. You should contact emergency personnel if you have symptoms of anaphylaxis, which may include:
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